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فیبروز ریوی
Using several elegant in vivo strategies to globally deplete monocytes and macrophages, Gibbons and colleagues concluded that macrophages are critically required for the development of bleomycin-induced pulmonary fibrosis (Gibbons et al.
In models of idiopathic pulmonary fibrosis, the pro-fibrotic function of macrophages has also been attributed to their pro- duction and activation of the pro-fibrotic cytokine TGF-b1 (Mur- ray et al.
Serum amyloid P, a member of the pentraxin family, has been shown to inhibit the accumulation of pro-fibrotic macrophages in the lungs of mice after bleomycin exposure, suggesting that it might be developed as a therapeutic strategy for idiopathic pulmonary fibrosis (Murray et al.
Hypoxia-inducible fac- tor-1a mediates TGF-b-induced PAI-1 production in alveolar macrophages in pulmonary fibrosis.
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